You can combine the linear workflow, i.e. working with regions on the timeline, and the non-linear workflow, i.e. launching clips from trigger slots and setting up follow actions.

FIXME GENERAL ORDER OF ACTION:

1. 1. Set up follow actions, follow count etc. It's up to you if you want transitions between scenes through follow actions. You can set slots to use Again follow action and add markers treiggering cues where you need them and adding "stop all cues" marker where you need all cues off.
2. Add cue markers.
3. Add the "stop all cues" marker
4. Draw/record your non-repeatable regions the usual way on the timeline/canvas.